Serotonin has early, cilia-independent roles in Xenopus left-right patterning
نویسندگان
چکیده
منابع مشابه
Serotonin has early, cilia-independent roles in Xenopus left-right patterning
Consistent left-right (LR) patterning of the heart and viscera is a crucial part of normal embryogenesis. Because errors of laterality form a common class of birth defects, it is important to understand the molecular mechanisms and stage at which LR asymmetry is initiated. Frog embryos are a system uniquely suited to analysis of the mechanisms involved in orientation of the LR axis because of t...
متن کاملLeft-right patterning in Xenopus conjoined twin embryos requires serotonin signaling and gap junctions.
A number of processes operating during the first cell cleavages enable the left-right (LR) axis to be consistently oriented during Xenopus laevis development. Prior work showed that secondary organizers induced in frog embryos after cleavage stages (i.e. conjoined twins arising from ectopic induced primary axes) correctly pattern their own LR axis only when a primary (early) organizer is also p...
متن کاملSerotonin transporter function is an early step in left-right patterning in chick and frog embryos.
The neurotransmitter serotonin has been shown to regulate a number of embryonic patterning events in addition to its crucial role in the nervous system. Here, we examine the role of two serotonin transporters, the plasma membrane serotonin transporter (SERT) and the vesicular monoamine transporter (VMAT), in embryonic left-right asymmetry. Pharmacological or genetic inhibitors of either SERT or...
متن کاملLeft–right development: The roles of nodal cilia
Cilia on the ventral side of the mouse node have been implicated in initiating the left-right axis during embryonic development, but how cilia relate to other factors in the left-right pathway and the mechanism by which cilia convey patterning information remain uncertain.
متن کاملXCR2, one of three Xenopus EGF-CFC genes, has a distinct role in the regulation of left-right patterning.
Members of the EGF-CFC family facilitate signaling by a subset of TGFbeta superfamily ligands that includes the nodal-related factors and GDF1/VG1. Studies in mouse, zebrafish, and chick point to an essential role for EGF-CFC proteins in the action of nodal/GDF1 signals in the early establishment of the mesendoderm and later visceral left-right patterning. Antisense knockdown of the only known ...
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2012
ISSN: 1754-8411,1754-8403
DOI: 10.1242/dmm.010256